Regulators of regulatory pathway: Quorum sensing

All displayed regulators are experimentally validated.


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0019 experimental PC1_3721 (Hfq) T6SS01001 insolico protein QS regulatory pathway Pectobacterium carotovorum subsp. carotovorum PC1 chromosome (CP001657) 4199890..4200189 (-) 251756660 hcp expression (↓)
REG0299 experimental VCA1552_RS00505 (hfq) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 92673..92936 (+) 446974616 VCA1552_00351 (HapR) (↑)
REG0344 experimental BN49_RS26620 (hfq) T6SS01214 experimental protein QS regulatory pathway Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 5173711..5174019 (-) 488974767 TssB transcription (↓)
REG0367 experimental H78_RS02920 (Hfq) - protein QS regulatory pathway Pseudomonas protegens strain H78 chromosome (NZ_CP013184) 662937..663197 (+) 495196588 T6SS transcription level (↓)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0147 experimental FTT1557c/FNU0663.2 (pmrA) T6SS00081 experimental protein TCS-RR Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 1618742..1619428 (-) 489108239 T6SS transcription (↓)
REG0176 experimental FTN_1465 (pmrA) T6SS00158 experimental protein TCS-RR; TCS regulatory pathway Francisella tularensis subsp. novicida U112 chromosome (NC_008601) 1553358..1554044 (-) 489108239 FTN_1465 (pmrA) promotor (↓); pdpD promotor (↓); IglA expression (↓)
REG0067 experimental PA3477 (RhlR) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889925..3890650 (-) 15598673 T6SS transcript (↓)
REG0154 experimental BTH_I0691 (Zur) T6SS00114 experimental protein Global regulator Burkholderia thailandensis E264 chromosome (NC_007651) 796074..796538 (-) 497578547 BTH_RS09735 (T6SS-4) Promotor,−541 to −1 relative to the ATG start codon (↑)
REG0366 experimental YPK_RS19410 (Zur) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 4251751..4252260 (+) 488143439 T6SS4 transcription (↓)
REG0296 experimental VCA1552_RS03895 (LuxO) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 818142..819509 (+) 487814784 Hcp expression and secretion (↑)
REG0023 experimental GPY04_RS00870 (HapR) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 164935..165546 (-) 446262243 Unknown (↓)
REG0112 experimental VP2516 (opaR) T6SS00043 experimental; T6SS00044 experimental protein QS regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2653215..2653829 (+) 28899290 vp1407 (↑); VP1388 promotor (↑); VP1400 promotor (↑); VP1409 promotor (↑); T6SS2 (Hcp2) expression and secretion (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1043-1028 transcript (↓); VPA1044-1046 transcript (↓)
REG0118 experimental VP2516 (OpaR) T6SS00043 experimental protein Global regulator Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2653215..2653829 (+) 28899290 T6SS1 (↓)
REG0122 experimental VF2177 (LitR) T6SS00084 experimental protein QS regulatory pathway Aliivibrio fischeri ES114 chromosome (NC_006840) 2446537..2447142 (+) 59712784 Unknown (↓)
REG0275 experimental V12G01_21538 (LuxR) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000053) 13551..14165 (-) 91187814 T6SS2 transcripts (↓); V12G01-18672 (vqsA) promotor
REG0293 experimental VCA1552_00351 (HapR) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 340447..341058 (-) 446262243 Unknown; Hcp expression and secretion
REG0355 experimental N779_15250 (VtpR) T6SS01280 experimental; T6SS01281 experimental protein QS regulatory pathway Vibrio coralliilyticus OCN008 chromosome (AVOO01000045) 7579..8184 (-) 536747482 Unknown (↓)
REG0301 experimental VCA1552_RS12025 (crp) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2558371..2559003 (+) 446164894 Hcp expression and secretion (↓)
REG0297 experimental VCA1552_RS17020 (cqsa) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024868) 455238..456407 (-) 446962656 Hcp expression and secretion (↓)
REG0111 experimental VP2762 (AphA) T6SS00043 experimental; T6SS00044 experimental protein QS regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2929909..2930448 (+) 28899536 T6SS1 transcript (↑); T6SS2 (VPA1027-1024, VPA1043-1028,VPA1044-1046) transcripts (↑)
REG0287 experimental V12G01_14830 (aphA) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000027) 42305..42880 (+) 91188695 V12G01-18672 (vqsA) promotor
REG0066 experimental PA3476 (rhlI) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889139..3889744 (-) 15598672 PA3477 (RhlR) (↓)
REG0327 experimental WQ49_05060 (cepI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 547435..548043 (+) 815852485 T6SS expression (↓)
REG0065 experimental PA1430 (LasR) T6SS00004 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1558171..1558890 (+) 15596627 H2-T6SS promotor P (hsiA2) (↓)
REG0166 experimental PA14_45960 (lasR) T6SS00152 experimental; T6SS00151 experimental; T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4085339..4086058 (-) 489173455 TssA2 (PA14_43050) promotor (↓); HSI-III transcripts (↓); HSI-I transcripts (↑)
REG0155 experimental BTH_II1510 (BtaR1) T6SS00115 experimental protein QS regulatory pathway Burkholderia thailandensis E264 chromosome (NC_007650) 1779070..1779789 (-) 497583165 BTH_I2691/BTH_I2693-99/BTH_I2701-702 (↓)
REG0324 experimental WQ49_05050 (cepR) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 545988..546707 (-) 815852483 T6SS promotor (P (BCAL0340) ) (↓)
REG0325 experimental WQ49_20245 (cciR) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000016) 843677..844378 (+) 815850423 Unknown (↑)
REG0195 experimental YPK_RS08345 (YpsR) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1837676..1838413 (+) 488140651 T6SS transcripts (↓)
REG0196 experimental YPK_RS03965 (YtbR) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 900476..901219 (+) 488140447 T6SS transcripts (↓)
REG0168 experimental PA14_51380 (pqsE) T6SS00150 experimental; T6SS00152 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4566077..4566982 (-) 489176725 T6SS Transciption (↓)
REG0093 experimental ECA_RS00520 (expI) T6SS00040 experimental protein QS regulatory pathway Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 125689..126339 (+) 499404281 T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0197 experimental YPK_RS08350 (ypsI) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1838406..1839050 (-) 501053391 T6SS transcripts (↓)
REG0198 experimental YPK_RS03970 (ytbI) T6SS00256 insolico; T6SS00260 experimental protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 901200..901850 (-) 488144695 T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0322 experimental GT391_RS06405 (expI) T6SS01170 experimental protein QS regulatory pathway Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 1436931..1437581 (-) 497970044 GT391_RS06470 (expR1) (↓)
REG0121 experimental CV_RS23145 (CviI) T6SS00049 insolico protein QS regulatory pathway Chromobacterium violaceum ATCC 12472 chromosome (NC_005085) 4426967..4427620 (-) 499450174 CV_RS20220 (CviR) (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0019 experimental PC1_3721 (Hfq) T6SS01001 insolico protein QS regulatory pathway Pectobacterium carotovorum subsp. carotovorum PC1 chromosome (CP001657) 4199890..4200189 (-) 251756660 hcp expression (↓)
REG0299 experimental VCA1552_RS00505 (hfq) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 92673..92936 (+) 446974616 VCA1552_00351 (HapR) (↑)
REG0344 experimental BN49_RS26620 (hfq) T6SS01214 experimental protein QS regulatory pathway Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 5173711..5174019 (-) 488974767 TssB transcription (↓)
REG0367 experimental H78_RS02920 (Hfq) - protein QS regulatory pathway Pseudomonas protegens strain H78 chromosome (NZ_CP013184) 662937..663197 (+) 495196588 T6SS transcription level (↓)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0147 experimental FTT1557c/FNU0663.2 (pmrA) T6SS00081 experimental protein TCS-RR Francisella tularensis subsp. tularensis SCHU S4 chromosome (NC_006570) 1618742..1619428 (-) 489108239 T6SS transcription (↓)
REG0176 experimental FTN_1465 (pmrA) T6SS00158 experimental protein TCS-RR; TCS regulatory pathway Francisella tularensis subsp. novicida U112 chromosome (NC_008601) 1553358..1554044 (-) 489108239 FTN_1465 (pmrA) promotor (↓); pdpD promotor (↓); IglA expression (↓)
REG0067 experimental PA3477 (RhlR) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889925..3890650 (-) 15598673 T6SS transcript (↓)
REG0154 experimental BTH_I0691 (Zur) T6SS00114 experimental protein Global regulator Burkholderia thailandensis E264 chromosome (NC_007651) 796074..796538 (-) 497578547 BTH_RS09735 (T6SS-4) Promotor,−541 to −1 relative to the ATG start codon (↑)
REG0366 experimental YPK_RS19410 (Zur) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 4251751..4252260 (+) 488143439 T6SS4 transcription (↓)
REG0296 experimental VCA1552_RS03895 (LuxO) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 818142..819509 (+) 487814784 Hcp expression and secretion (↑)
REG0023 experimental GPY04_RS00870 (HapR) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 164935..165546 (-) 446262243 Unknown (↓)
REG0112 experimental VP2516 (opaR) T6SS00043 experimental; T6SS00044 experimental protein QS regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2653215..2653829 (+) 28899290 vp1407 (↑); VP1388 promotor (↑); VP1400 promotor (↑); VP1409 promotor (↑); T6SS2 (Hcp2) expression and secretion (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1043-1028 transcript (↓); VPA1044-1046 transcript (↓)
REG0118 experimental VP2516 (OpaR) T6SS00043 experimental protein Global regulator Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2653215..2653829 (+) 28899290 T6SS1 (↓)
REG0122 experimental VF2177 (LitR) T6SS00084 experimental protein QS regulatory pathway Aliivibrio fischeri ES114 chromosome (NC_006840) 2446537..2447142 (+) 59712784 Unknown (↓)
REG0275 experimental V12G01_21538 (LuxR) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000053) 13551..14165 (-) 91187814 T6SS2 transcripts (↓); V12G01-18672 (vqsA) promotor
REG0293 experimental VCA1552_00351 (HapR) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 340447..341058 (-) 446262243 Unknown; Hcp expression and secretion
REG0355 experimental N779_15250 (VtpR) T6SS01280 experimental; T6SS01281 experimental protein QS regulatory pathway Vibrio coralliilyticus OCN008 chromosome (AVOO01000045) 7579..8184 (-) 536747482 Unknown (↓)
REG0301 experimental VCA1552_RS12025 (crp) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2558371..2559003 (+) 446164894 Hcp expression and secretion (↓)
REG0297 experimental VCA1552_RS17020 (cqsa) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024868) 455238..456407 (-) 446962656 Hcp expression and secretion (↓)
REG0111 experimental VP2762 (AphA) T6SS00043 experimental; T6SS00044 experimental protein QS regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2929909..2930448 (+) 28899536 T6SS1 transcript (↑); T6SS2 (VPA1027-1024, VPA1043-1028,VPA1044-1046) transcripts (↑)
REG0287 experimental V12G01_14830 (aphA) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000027) 42305..42880 (+) 91188695 V12G01-18672 (vqsA) promotor
REG0066 experimental PA3476 (rhlI) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889139..3889744 (-) 15598672 PA3477 (RhlR) (↓)
REG0327 experimental WQ49_05060 (cepI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 547435..548043 (+) 815852485 T6SS expression (↓)
REG0065 experimental PA1430 (LasR) T6SS00004 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1558171..1558890 (+) 15596627 H2-T6SS promotor P (hsiA2) (↓)
REG0166 experimental PA14_45960 (lasR) T6SS00152 experimental; T6SS00151 experimental; T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4085339..4086058 (-) 489173455 TssA2 (PA14_43050) promotor (↓); HSI-III transcripts (↓); HSI-I transcripts (↑)
REG0155 experimental BTH_II1510 (BtaR1) T6SS00115 experimental protein QS regulatory pathway Burkholderia thailandensis E264 chromosome (NC_007650) 1779070..1779789 (-) 497583165 BTH_I2691/BTH_I2693-99/BTH_I2701-702 (↓)
REG0324 experimental WQ49_05050 (cepR) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 545988..546707 (-) 815852483 T6SS promotor (P (BCAL0340) ) (↓)
REG0325 experimental WQ49_20245 (cciR) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000016) 843677..844378 (+) 815850423 Unknown (↑)
REG0195 experimental YPK_RS08345 (YpsR) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1837676..1838413 (+) 488140651 T6SS transcripts (↓)
REG0196 experimental YPK_RS03965 (YtbR) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 900476..901219 (+) 488140447 T6SS transcripts (↓)
REG0168 experimental PA14_51380 (pqsE) T6SS00150 experimental; T6SS00152 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4566077..4566982 (-) 489176725 T6SS Transciption (↓)
REG0093 experimental ECA_RS00520 (expI) T6SS00040 experimental protein QS regulatory pathway Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 125689..126339 (+) 499404281 T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0197 experimental YPK_RS08350 (ypsI) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1838406..1839050 (-) 501053391 T6SS transcripts (↓)
REG0198 experimental YPK_RS03970 (ytbI) T6SS00256 insolico; T6SS00260 experimental protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 901200..901850 (-) 488144695 T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0322 experimental GT391_RS06405 (expI) T6SS01170 experimental protein QS regulatory pathway Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 1436931..1437581 (-) 497970044 GT391_RS06470 (expR1) (↓)
REG0121 experimental CV_RS23145 (CviI) T6SS00049 insolico protein QS regulatory pathway Chromobacterium violaceum ATCC 12472 chromosome (NC_005085) 4426967..4427620 (-) 499450174 CV_RS20220 (CviR) (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)